Atin Supiyani, Aulia Annisa, Renhat Limbong, Imam Nur Alamsyah, Rusdi
Allergies are immune system responses that can cause physiological stress and tissue damage. Pearl grass (Oldelandia corymbose) has been found to have health benefits such as anticancer, antiallergic, anti-inflammatory, and immunomodulatory activity. The purpose of this study was to determine the bioactivity of Pearl Grass Extract (PGE) against allergic mice. A total of 35 male DDY mice aged 2 months were divided into 7 groups, namely (1) normal; (2) ovalbumin (OVA); (3) OVA + PGE 120, (4) OVA + PGE 200, (5) OVA+PGE 280, (6) OVA+PGE360 and (7) OVA+PGE440 mg/Kg BW. The variable measured was the lethal dose 50 (LD-50) from PGE using the BSLT method, the stress index was calculated from the neutrophil/lymphocyte ratio, and the macrophage alveolar was calculated from histological staining. The results showed that LD-50 for PGE was 235,881 mg/Kg BW, a moderately toxic category. The stress index of all groups given OVA+PGE was significantly different from the OVA group (p<0.05). Mice were given OVA+PGE 360 and 440 mg/Kg BB showed a stress index value of <1.5. The alveolar macrophages of mice given 200 and 440 mg/Kg of body weight were significantly different from the OVA group (p<0.05). It can be concluded that. The dose of pearl grass extracts 360 mg/Kg BW was effective in reducing the stress index value below 1.5 in allergic mice. Pearl grass extract doses of 200 mg/Kg BW effectively reduced the number of alveolar macrophages in allergic mice. It is worth further research on different types of allergies. © 2024 American Institute of Physics Inc.. All rights reserved.
Biology Study Program, Faculty of Mathematics and Natural Sciences, State University of Jakarta, Jl. Rawamangun Muka No.11 East Jakarta, Jakarta, 13220, Indonesia; Biology Education Study Program, Faculty of Mathematics and Natural Sciences, State University of Jakarta, Jl. Rawamangun Muka No. 11 Rawamangun, East Jakarta, Jakarta, 13220, Indonesia
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