Babay Asih Suliasih, Dwi Giwang Kurniawan, Marissa Angelina, Setia Budi, Haliza Katas
Gold nanoparticles (AuNPs) have attracted much attention as one of the most effective agents with high catalytic activities for radical scavenging reactions. Many studies have investigated its antioxidant activity using various in vitro methods and have shown promising scavenging action. In this research, we demonstrated the synthesis of Au nanofilms (AuNFs) by cyclic voltammetry technique and evaluated for their antioxidant activity. The application of a range of voltage levels was utilized in the synthesis of AuNFs, and their antioxidant potential was subsequently assessed through in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. All AuNFs exhibited antioxidant activity which increased as the upper potential was reduced from 1,5 V to 0,75 V. The antioxidant activity of AuNFs was shown to increase gradually with longer incubation times before the DPPH assay, indicating a significant impact on their performance. The obtained inhibition percentage was ranging from 8,26% to 22,91%. The highest antioxidant activity could be achieved by synthesizing AuNFs using 0,75V of upper potential and incubating it for 90 minutes prior to DPPH assay. The variations in the applied potential influenced the morphological characteristics of AuNFs, leading to increased surface area, while the duration of incubation was found to enhance the efficacy of the scavenging reaction between the AuNFs and DPPH. In conclusion, this cyclic voltammetry technique was shown to successfully synthesize AuNFs with significant antioxidant activity. © Published under licence by IOP Publishing Ltd.
Centre for Drug Delivery Technology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia; Department of Chemistry, Faculty of Mathematics and Science, Universitas Negeri Jakarta, Jl. Rawamangun Muka, Jakarta, 13220, Indonesia; Research Centre for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Kawasan PUSPIPTEK Serpong, Selatan Banten, Tangerang, 15314, Indonesia
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