Yulia Irnidayanti, Fudchus Tifany Nabilah, Nina Herlina
Background and Objective: Aluminum (Al) is widely used in many aspects of daily life, such as food packaging, cooking utensil components, food additives, cosmetics and water distillation. This study aimed to evaluate the protective role of nanocurcumin on the cerebral cortex of one and two-month-old mice exposed to 200 mg kgG1 b.wt., aluminium. Materials and Methods: The Swiss Webster mice were used in this study. The control group only received sterile distilled water, the Al group was administered 200 mg kgG1 b.wt., of AlCl3 solution and the Al+Na Cur group was administered 200 mg kgG1 b.wt., AlCl3+200 mg kgG1 nanocurcumin by intraperitoneal injection. The nanocurcumin was administered one hour after AlCl3 exposure and then on days 0, 3, 6, 9, 12, 15, 18, 21, 24, 27 and 30. All the mice were anaesthetized and their brains were collected and fixed in a neutral formalin buffer solution for histological analysis. The paraffin method was used in this study. Results: The death of granular neuron cells and karyolysis cells and the vacuolation of the pyramid cell layer of the cerebral cortex could be prevented by the intraperitoneal administration of nanocurcumin. The effect of nanocurcumin administration on the Al group at two months of age was more effective than on the Al group at one month of age. Conclusion: Nanocurcumin can be a promising candidate protective agent against cerebral cortex changes after aluminium administration. © 2022 Yulia Irnidayanti et al.
Biology Study Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Hasyim Asyarie Building, Rawamangun Muka, Jakarta, Indonesia; Department of Animal Biotechnology, Indonesian Institute of Sciences, Bogor, 16911, Indonesia
Research at a Glance
Register to unlock
Topics & SDG Alignment
Register to unlock
Collaboration
Register to unlock
Author Profile (Selected)
Register to unlock
References Overview
Register to unlock
Journal & Source
Register to unlock
Metadata & Integrity
Register to unlock