Purwantiningsih Sugita, Widya Sekar Ayu Ningtias, Rafi Chandra Priandanda, Auliya Ilmiawati, Kurniawanti, Dhea Demitri Agusta, Hanhan Dianhar, Dyah Utami Cahyaning Rahayu
Biflavonoids are a distinctive class of dimeric flavonoids known for their diverse biological activities and chemotaxonomic significance. In this study, two biflavonoids were isolated from the acetone extracts of Araucaria hunsteinii twigs and Araucaria columnaris leaves collected from Bogor Botanical Garden, Indonesia. Chromatographic techniques, including Sephadex LH-20 column chromatography and preparative thin-layer chromatography, were employed for purification, followed by structural elucidation using LC-MS/MS and 1D/2D NMR spectroscopy. The compounds were identified as 4',4''',7,7''-tetra-O-methylcupressuflavone (1) and 7-O-methylcupressuflavone (2). Notably, this is the first report of 7-O-methylcupressuflavone isolated from A. columnaris leaves, providing new chemotaxonomic insights into the genus Araucaria. A literature-based pharmacological analysis revealed promising cytotoxic and α-glucosidase-inhibitory activities of the isolated compounds. These findings contribute to the phytochemical profiling and highlight the pharmaceutical potential of Araucaria-derived biflavonoids. © 2025 The Author(s).
Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, West Java, Bogor, 16680, Indonesia; Chemistry Study Program, Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, West Java, Bogor, 16680, Indonesia; Chemistry Study Program, Faculty of Mathematics and Natural Sciences (FMIPA), Jakarta State University, Jakarta, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, Indonesia
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