E. Lisanti, D. Sajuthi, M. Agil, R.I. Arifiantini, A. Winarto
Neem has antispermatogenic effect in animals and male men. The objectives of this research to evaluate the effect of aqueous seed extract of neem on the structure of testis. Male mice of DDY strain were divided into five groups. Group I as a control group (C1-1) with the absence of treatment. Group II and III (s1-1 and s2-1) were orally treated by administered aqueous seeds extract of neem at doses 0.25 and 0.50 mg/kg body weight (bw) for 36 days. Group IV and V (S1-2 and S2-2) was treated by administering aqueous seeds extract of neem at doses 0.25 and 0.50 mg/kg bw for 36 days followed with another 36 days with no treatment. The results showed that neem seed extracts cause a decrease of spermatogenic cell (p < 0.05). It can be concluded that exposure to the aqueous seed extracts of neem can decrease spermatogenic cell, and its effect more than 36 days. © Published under licence by IOP Publishing Ltd.
Reproductive Biology in Department of Veterinary Clinic, Reproduction and Pathology, Faculty of Veterinary Medicine, Institut Pertanian, Bogor, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Jakarta, Indonesia; Department of Veterinary Clinic, Reproduction and Pathology, Faculty of Veterinary Medicine, Institut Pertanian Bogor, Indonesia; Departement Anatomy Physiology and Pharmacology, Faculty of Veterinary Medicine, Institut Pertanian Bogor, Indonesia
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