Taghreed Hassanin Ibrahim Mohammed, Hesham Ali El Enshasy, Mohamad Hamdi Zainal Abidin, Li Ting Tan, Dalia Sukmawati, Mohammad Alim Jafari
The increasing need for environmentally friendly solvents in the pharmaceutical field highlights the significance of developing novel strategies to address various obstacles. The primary focus of this review is on the advancement of novel active pharmaceutical ingredient (API) based DES called therapeutic deep eutectic solvents (THEDESs), with a comprehensive investigation into their different physicochemical characteristics such as thermal stability, viscosity, and surface tension. Furthermore, an in-depth analysis was conducted to assess the multifunctional capabilities of the prepared THEDES, specifically in terms of their antioxidant and antimicrobial properties. The outcomes of this study significantly contribute to the knowledge advancement regarding THEDESs, shedding light on their potential to address sustainability challenges in the pharmaceutical industry. Moreover, the study results highlight the encouraging possibilities offered by THEDESs in drug delivery systems and therapeutic treatments, suggesting a prospective shift in pharmaceutical approaches towards more sustainable and effective resolutions. © 2025 by SPC (Sami Publishing Company).
Demaprtment of Chemistry, Faculty of Science, Universiti Teknologi Malaysia (UTM), Johor, Malaysia; Innovation Centre in Agritechnology for Advanced Bioprocessing (ICA), Universiti Teknologi Malaysia (UTM), Johor, Malaysia; Faculty of Chemical and Energy Engineering, Universiti Teknologi Malayisa (UTM), Johor, Malaysia; City of Scientific Research and Technology Applications (SRTA), Alexandria, New Burg Al Arab, Egypt; Sateera Sdn. Bhd, Taman Ekoperniagaan, Johor, Senai, Malaysia; Biology Department, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta (UNJ), Jakarta, Indonesia; School of chemistry, faculty of Science, Monash university, Rowan Dr, Doveton, 3177, VIC, Australia
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