Fera Kurniadewi, Richard Anugerah Tigor, Muktiningsih, Irma Ratnakartika, Euis Holisotan Hakim, Lia Dewi Juliawaty
Two α-pyrone compounds cryptofolione (1) and cryptofolione ketone (2) have been isolated from chloroform fraction of the leaves of Cryptocarya konishii Hayata. The structures of these compounds were determined based on the analysis of spectroscopic data including UV, IR, 1D and 2D NMR. The isolated compounds were evaluated for their cytotoxic activities against murine leukemia P-388 cells. Compound 1 was found more active than compound 2 with IC50 by 0.84 μg/mL. The antioxidant evaluation of both compounds against 2,2-diphenyl-1-picrylhydrazyl (DPPH) was of very low activities (IC50 2.59×104 and 1.28×109 ppm respectively). © 2019 World Research Association. All rights reserved.
Chemistry Study Program, Universitas Negeri Jakarta, Gedung Hasyim Anshari Lantai 5, Jalan Rawamangun Muka, Jakarta, 13220, Indonesia; Chemistry Study Program, Institut Teknologi Bandung, Jalan Ganeca 10, Bandung, Jawa Barat, Indonesia
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