Nuniek Ina Ratnaningtyas, Hernayanti, Suci Andarwanti, Nuraeni Ekowati, Endang Sri Purwanti, Dalia Sukmawati
Diabetes mellitus (DM) is a metabolic syndrome which occurs when insulin is in-sufficiently produced or insulin cannot well serve its function. Diabetes is marked with increase in blood glucose level followed by increase in glycosylated hemoglo-bin level and decrease in insulin level. This research aims to examining the effect of Ganoderma lucidum extract on the blood glucose, insulin and glycosylated hemo-globin (HbA1c) level of diabetic white rat and determining the most effective dose of extract to be a diabetic agent. This research was experimentally conducted by employing Completely Randomized Design (CRD) with 6 treatments and 4 repetitions. The treatment groups consisted of healthy rats group (K1), rats with diabetes as negative control (K2), diabetic rats with the administration of metformin 45 mg/kg BW as the comparison (K3) and diabetic rats with the administration of G. lucidum extract with dose of 250, 500 and 1000 mg /kg BW (K4, K5 and K6 respectively). Blood glucose level examination was conducted after the alloxan in-duction with single dose of 125 mg/kg BW by intraperitoneal injection. The results show that mushroom G. lucidum extract administration with dose of 1000 mg/kg BW (K6) is the best dose to be an anti-diabetic agent. The benefit of the research is developing anti-diabetic agent from herbal resources. © 2018, Universitas Negeri Semarang. All rights reserved.
Department of Microbiology, Faculty of Biology, Universitas Jenderal Soedirman, Indonesia; Department of Microbiology, Faculty of Biology, Universitas Negeri Jakarta, Indonesia
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